Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium much more commonly appearing in the lower. Histopathology of ameloblastoma of the jaws; some critical observations based on a 40 years single institution experience. Doenja Hertog 1. Cases Series. Rui Henriques Martins Josias de Andrade Sobrinho AbrĂ£o Rapoport Marilene Paladino Rosa. Histopathologic features and management of .

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It is a tumor of the enamel organ without formation of enamel. Robinson has defined it ameloblstoma Unicentric, nonfunctional, intermittent in growth, anatomically benign and clinically persistent.

The importance of this tumor lies in its common occurrence, locally invasive behavior which causes marked deformity and serious debilitation.

They also demonstrate increased recurrence rate after surgery. Mandibular ameloblastoma presenting as swelling causing facial asymmetry. Clinics and Pathology Note History: Gorlin identifies Cusack as the first person to identify ameloblastoma in Falkson gave a detailed description in Wagstaffe amekoblastoma the first histological drawing. Malassez introduced the term adamantine epithelioma while Derjinsky introduced the term adamantinoma.

However, this term has become obsolete and has to be avoided. Ivy and Churchill in encouraged the use of the term Ameloblastoma which is the preferred terminology till date.

Embryonic origin Ameloblastoma arise from remnants of odontogenic epithelium i. If these rests are situated outside the bone in the soft tissues of gingiva or hisotpathology mucosa may give rise to peripheral ameloblastoma. Other possible sources of origin include gingival surface epithelium and lining of odontogenic cysts. They usually occur in middle age group i.

Head and Neck: Odontogenic tumor: Ameloblastoma

They are rare in children 8. Maxillary ameloblastoma and extraosseous ameloblastoma occur in a slightly older age group while unicystic ameloblastoma Avg It shows equal sex predilection with no specific racial predominance.

There is conflicting evidence on the incidence rates in different races. Although some reports claim an increased incidence of ameloblastoma in black individuals, a large study identifies Asians as the population with greatest number of affected patients.

Ameloblastoma occurs in all areas of jaws, but the mandible is the most commonly affected area i. Within the mandible, the molar angle ramus area is involved three times more commonly than are premolar and anterior regions combined. In the maxilla, most usually occur in the molar area, but may be seen occasionally in the anterior region, maxillary sinus and nasal cavity.

Based on the clinical, radiographic, histopathologic and behavioral aspects, four subtypes of ameloblastoma are currently identified namely: Most patients thus typically present with a complaint of swelling and facial asymmetry. Occasionally, small tumors may be identified on routine radiography. As the tumor enlarges, it forms a hard swelling and later may cause thinning of the cortical bone resulting in an egg shell crackling which can be elicited.

The slow growth also allows for reactive bone formation leading to gross enlargement and distortion of the jaw. If the tumor is neglected, it may perforate the bone and spread into the soft tissues making excision extremely difficult. Ameloblastomw has been reported as an amelblastoma finding which could be attributed to secondary infection.

Other effects include tooth mobility, displacement of teeth, resorption of roots, paraesthesia if the inferior alveolar canal is involved, failure of eruption of teeth and very rarely the ameloblastoma can ulcerate through the mucosa. Peripheral ameloblastoma usually presents as normal colored, yistopathology surfaced nodules or enlargements but occasional tumors may present with erythematous or papillary surface. They are slow growing and cause little or no bone erosion.


Any saucerisation of the underlying bone is due to pressure rather than invasion. Ameloblastoma usually present as a well defined, multilocular radiolucency with scalloped border typically described as ‘honeycomb’ or soap bubble appearance.

However, unicystic ameloblastoma typically amelloblastoma as a unilocular radiolucency containing an impacted tooth. They typically infiltrate through the medullary bone, therefore the radiographic margins are not accurate indicators of the extent of involvement.

Expansion of buccal and lingual cortical plates, displacement and root resorption may also be seen. Desmoplastic ameloblastoma present with a ill-defined radiolucent radiopaque lesion reminiscent of a fibro-osseous lesion. Cytology Ameloblatoma cytologically usually presents with basaloid cells arranged in cells and clusters.

These basaloid cells have scanty cytoplasm and dense oval nucleus.

Palisading of these basaloid cells in hostopathology clusters is a noticable feature. Additionally, squamous cells with abundant cytoplasm and central nucleus can also be seen if there is evidence of squamous metaplasia.

The background is usually eosinophilic aameloblastoma shows scattered spindle cells and inflammatory cells. Ameloblastoma presenting as a multilocular radiolucency involving the left mandibular angle and ramus region. Unicystic ameloblastoma presenting as an unilocular radiolucency associated with an impacted mandibular third molar.

Desmoplastic ameloblastoma depicting a ill-defined radiolucency with specks of radiopacities in mandibular anterior region. Pathology There are six histopathologic subtypes which have been identified for ameloblastoma i.


Mixtures of different patterns are commonly observed and the lesions are usually classified based on the predominant pattern present. These are most readily recognizable and common type of ameloblastoma histologically.

The follicular pattern consist of islands of epithelial cells with a central mass of polyhedral cells or loosely arranged angular cells resembling stellate reticulum, surrounded by well organized single layer of cuboidal or tall columnar cells with nuclei placed at the opposite pole of basement membrane resembling pre-ameloblasts.

This peripheral cell layer tends to show cytoplasmic vacuolization. Cystic formation is often seen in the center of the epithelial islands due to degeneration of stellate reticulum like cells.

Cyst formation occurs but is usually due to stromal degeneration rather than cystic change in the epithelium. The stroma consists of loose, vascular sparsely cellular connective tissue. It resembles a typical follicular ameloblastoma except it shows extensive squamous metaplasia sometimes with keratin formation within the epithelial islands. When the central stellate reticulum cells show extensive granular cell transformation i.

Sometimes this change, may be so extensive that the peripheral columnar cells may also be replaced making the diagnosis difficult especially in a small biopsy. Ultrastructurally, it is seen that the granules consist of pleomorphic, osmiophilic, lysosome like organelles.

This variant shows predominant basaloid pattern consisting of darkly stained cells with minimal cytoplasm and little evidence of palisading at the periphery resembling those seen in basal cell carcinoma.

This variant was first described in detail by Eversole et al. Cyst formation is common and ameloblast like areas are present only in small foci. Calcification in the fibrous stroma and occasional bone formation can also be seen.


Histochemical evaluation of the collagen suggests that the dense stroma is not scar tissue but represents active denovo synthesis of extracellular matrix proteins. It typically presents radiographically as a mixed radiolucency and radiopacity mimicking a fibrosseous lesion.

In contrast to typical ameloblastoma, this variant frequents the maxilla and the anterior region of the jaws. This is considered as an in-situ or superficially invasive form of ameloblastoma and consists of a single cyst lined by ameloblastic epithelium.

Pathology Outlines – Benign tumors / tumor-like conditions: ameloblastoma

It presents clinically similar to a dentigerous cyst and is usually associated with an impacted tooth usually 3rd molars. They are usually seen in younger patients with an average age of diagnosis being 22 years and generally involve the mandible. This variant histologically presents as a single cyst lined by ameloblastomatous epithelium and is divided into several subgroups based on pattern and extent of ameloblastomatous proliferation in relation to cyst wall.

Cystic lesion lined by epithelium which exhibits columnar differentiation and reverse polarization of the basal cell ameloblastoa. The connective hiistopathology adjacent to the epithelium often exhibits a uniform, thin band like area of hyalinization.

Luminal and intraluminal UA: Is the simple amelonlastoma but exhibits one or more nodules projecting into the lumen. No extension is seen into the surrounding connective tissue wall.

Occasionally, this form of UA can produce an intraluminal plexiform pattern of odontogenic epithelium that lacks typical ameloblastomatous differentiation and is called as unicystic plexiform ameloblastoma. Luminal, intraluminal and intramural UA: Here there is occurrence of intramural proliferation of ameloblastoma along with ameloblxstoma 1. Luminal and intramural UA: The intramural ameloblastoma tissue may be seen as an infiltration from the cyst lining or as free islands of follicular ameloblastoma.

They present histologically with follicular or plexiform pattern as well as acanthomatous pattern. In most cases, the tumor is well separated from the overlying epithelium but many are confluent with the overlying mucosa. Clear cell variant which may contain clear PAS positive cells are localized in the stellate reticulum like areas. Papilliferous keratoameloblastoma show occurrence of areas of ameloblastoma with keratinisation, tumor islands with papilliferrous appearance along with cystic areas resembling odontogenic keratocysts.

Mucous cells can also be demonstrated rarely in ameloblastoma. Photomicrograph depicting a typical follicular ameloblastoma with islands demonstrating peripheral columnar cells exhibiting reversal of polarity and central stellate-reticulum lie cells demonstrating cytic degeneration. Figure 3B and C: Photomicrographs depicting acanthomatous variant of ameloblastoma depicting follicles exhibiting extensive squamous metaplasia and keratin formation. Plexiform ameloblastoma with odontogenic epithelium arranged in the form of interlacing trabeculae and evidence of stromal degeneration.

Figure 4A and B: Photomicrographs depicting basaloid areas in an ameloblastoma. Photomicrographs depicting compressed epithelial islands surrounded by dense fibrous stroma with evidence of bone formation. Figure 5A and B: Luminal type and B: Figure 5C and D: Photomicrographs depicting mucous cells in ameloblastoma.

Treatment The diagnosis has to be confirmed by a biopsy, but occasionally in cystic variants it may be made only after excision.